Learn More. Oxycodone is most commonly snorted for its powerful, concentrated high. People that begin taking Oxycodone orally will often develop a tolerance to the drug and require increasing amounts for the same effects.
One way to adjust for tolerance is to switch routes of administration of the drug, i. Snorting oxycodone allows the drug to enter the bloodstream more quickly, providing a faster and more intense high. Snorting Oxycodone allows for more rapid ingestion as it bypasses the digestive tract and goes straight into the bloodstream through blood vessels in the nasal cavity. Upon entering the bloodstream, the drug quickly travels to the brain, causing effects to be felt shortly after snorting. Oxycodone may come in extended-release formulas, such as Oxycontin, that are intended to slowly release the drug throughout the day.
By crushing and snorting the pills, the extended-release mechanism is rendered obsolete and the effects are experienced immediately. What initially began as an adjustment for tolerance can quickly turn into an addiction.
The likelihood of developing an addiction to Oxycodone is significantly higher when a user administers the drug in ways other than prescribed. You start to enjoy the drip from snorting your pills, it becomes part of the enjoyment in your high.
Snorting Oxycodone not only produces an amplified high and higher rates of addiction, but also increases the risk of negative side effects and overdose. Make a Call Snorting Oxycodone is significantly more dangerous than taking the drug orally, and the effects can even be fatal. Snorting any drug is thought to increase the risk of contracting Hepatitis C due to damage to the blood vessels inside the nose and sharing snorting paraphernalia like dollar bills and straws.
The main consequences of snorting Oxycodone is damage to the nose, throat, and respiratory system. The effects of these health risks range from mild to life-threatening, and can include:. Because Oxycodone is a central nervous system CNS depressant, the risk for overdose is significantly higher when the drug is crushed and snorted due to the profound respiratory depression that can occur. Additionally, many people will also abuse alcohol and other drugs to amplify or mitigate the effects of snorting oxycodone.
Mixing oxycodone with CNS depressants significantly raises the risk of overdose as it can cause increased confusion and respiratory failure. Galloway, NJ. View Center.
Edwards, CO. With proper medical treatment, it is possible to recover from an overdose. However, if left untreated, it can cause irreversible damage to the brain and possibly even death.
Oxycodone use, regardless of the method of administration, is a very dangerous and potentially deadly habit. If you or someone that you know is snorting Oxycodone, contact a treatment provider today. People who snort drugs put themselves at a greater risk of drug dependence, overdose, and even death. The sooner you seek treatment, the greater the chances for a successful long-term recovery. Your doctor may start you on a lower dosage. For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well.
This may increase the levels of oxycodone in your body and cause more side effects. This medication may also decrease your kidney function, making your kidney disease worse. For people with seizure problems: Oxycodone may cause or worsen seizures. If you have epilepsy , talk with your doctor about whether this drug is safe for you. Oxycodone may make your condition worse. Your doctor may prescribe a lower dosage of this drug. For people with hypothyroidism low thyroid levels : Talk with your doctor about whether this drug is safe for you.
Oxycodone could make your condition better or worse. For people with urination problems: If you have trouble urinating due to certain problems, talk with your doctor about whether this drug is safe for you. These problems include an enlarged prostate, a bladder obstruction, or kidney problems. Oxycodone can make it even harder for you to urinate, or make you unable to urinate.
For people with pancreas and gallbladder problems: Oxycodone raises your risk of pancreatitis. If you have acute or chronic pancreatitis , this drug may worsen your condition. Talk with your doctor about whether this drug is safe for you. For pregnant women: Using oxycodone long term during pregnancy may cause withdrawal symptoms in your newborn child.
Symptoms include irritability, overactive behaviors, or an abnormal sleep pattern. They also include high-pitched crying, tremors, vomiting, diarrhea, or failure to gain weight.
This drug should only be used in pregnancy if clearly needed. For women who are breastfeeding: Oxycodone is present in breast milk and may cause side effects in a child who is breastfed.
Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. For seniors: The kidneys of older adults may not work as well as they used to. For people at risk of misuse, addiction, or overdose: Using oxycodone can lead to addiction and misuse, which can result in overdose or death.
Your doctor may prescribe naloxone, which is a drug used to treat an oxycodone overdose. Talk with your doctor or pharmacist about how to get or use naloxone. Oxycodone oral tablet is used for short-term or long-term treatment.
The length of treatment depends on how severe your pain is. If you stop taking the drug suddenly, you may have symptoms of withdrawal, which can include:. For this drug to work well, a certain amount needs to be in your body at all times. If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:. But if your symptoms are severe, call or go to the nearest emergency room right away.
If you think you might be at risk of misuse or overdose, talk with your doctor about naloxone. What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, skip the missed dose and go back to your regular dosing schedule. A prescription for this medication is not refillable. You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled.
You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:. Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it. Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.
There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date.
However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional.
You should always consult your doctor or other healthcare professional before taking any medication. Use of ondansetron along with tapering of the opioid was safe and effective in preventing further withdrawal symptoms.
This case should stimulate research with a larger, more diverse population including those with both short-term and chronic opioid dependence. Patients who have been prescribed an oral opioid postoperatively and who take the drug for 2 or more weeks usually report experiencing withdrawal symptoms when the drug is discontinued.
This report describes the case of an individual who was assisted in relieving her physical dependence on oxycodone.
It provides an insight into the reason for her surgery, the surgery itself, and her postoperative course. It also reviews medications used, and describes the protocol followed to produce successful results. The patient, a female, was 14 years old when she was diagnosed with scoliosis.
She showed no cosmetic effect, nor was there any pressure on her internal organs related to the scoliosis. At age 44, a rib on her left side became noticeably more prominent and measurements showed that she had lost close to two inches in height.
She was in good health and had a body mass index below Her only pain medication was an occasional extra-strength acetaminophen. An assessment by an orthopedic surgeon recommended by the Scoliosis Research Society revealed that she had also developed some neuropathy in her left lower limb.
A magnetic resonance imaging scan verified thoracic dextroscoliosis and lumbar levoscoliosis with degenerative changes in both areas. Surgery was deemed medically necessary. Her first surgery was accomplished through a lower abdominal incision.
Lumbar vertebra 5 L5 was replaced by a titanium prosthesis, and a donor bone graft was used to replace the disc. The next day, surgery was performed anteriorly from a left-side incision. A rib was removed, a chest tube was inserted, and discs between T10, T11, T12, and the remaining lumbar vertebrae were temporarily replaced. After surgery, the patient complained of quite a bit of referred pain in her shoulder.
She rested on days 3 and 4, but was back in surgery for several hours on day 5. Because the vertebra were scraped to allow fusion with the grafts, the patient required replacement of 14 U of blood.
Postoperatively, the patient had intravenous i. Epidural analgesia was attempted but did not provide any pain relief, so she was maintained on the PCA through day 7. On day 9 her controlled-release oxycodone dose was increased to 20 mg at a. Fast-release oxycodone 5 mg was continued for breakthrough pain. She was discharged from hospital that afternoon. The following days were difficult for her. During the first week at home the patient took approximately three oxycodone 5 mg tablets for breakthrough pain, but by the following week she was able to gradually discontinue it.
She became more active and was able to climb the stairs to the second floor of the house in spite of some left leg and foot neuropathy. She was anxious to be able to drive her car, but thought that she should not do so while she was still taking the controlled-release oxycodone.
Twenty-five days after receiving her first opioid and almost 3 weeks after discharge from the hospital, the patient discontinued the middle dose of oxycodone, contrary to usual pain management protocols, which recommend partial decreases at each dosage time over many days. She decided to take 20 mg of oxycodone at 8 a. She showed the following signs of withdrawal: crying, cold flashes, piloerection, muscle twitches, tremors, hot flashes, and perspiration. She described symptoms of: abdominal cramps, feeling nauseous and ready to vomit, shaking, and eye twitching.
These signs and symptoms lasted over 48 h. She was afraid to reduce the remaining doses of oxycodone and asked for assistance. A review of the literature was conducted through PubMed and yielded many articles dealing with withdrawal from opiates.
The study showed that naloxone could precipitate withdrawal signs and symptoms after acute morphine administration similar to those observed after chronic opioid use [ 1 ].
That same year, a scientist from the UK reviewed several studies and called attention to the fact that cerebral membranes of both the rat and humans contained sites that were characteristic of 5-hydroxytryptamine3 5-HT 3 receptors.
He posited that 5-HT 3 antagonists might have the ability to block feelings of reward induced by drug-craving addicts [ 2 ]. A Canadian study concluded that 5-HT 3 antagonists ondansetron, and MDL might reduce some, but not all, signs and symptoms of withdrawal behavior induced by naloxone [ 3 ].
Other researchers varied in their conclusions regarding the effectiveness of ondansetron. One study found that it did not reduce the cravings of opiate addicted rodents [ 4 ], while another suggested that it could be useful in lowering the rate of relapse [ 5 ].
Data reported by a group from Italy confirmed that naloxone precipitated withdrawal signs in morphine-dependent rats, and, that ondansetron prevented several of those signs [ 6 ].
In , a research group from Stanford University [ 7 ] assessed opioid withdrawal behavior in 18 different strains of mice and in eight human volunteers. The mice were treated with subcutaneous s.
The researchers used ondansetron, to determine its effect on the morphine-dependent mice. The ondansetron-treated mice showed significantly decreased naloxone-induced withdrawal behavior [ 7 ].
Eight human volunteers, all males, were then recruited, and served as their own controls. Baseline data were obtained by using objective and subjective rating scales [ 8 ]. Four volunteers received a 0. The remaining four volunteers were pretreated with 8 mg of ondansetron i. Seven days later the volunteers were administered the same drugs. The four men who had received placebos in the first experiment received both ondansetron and morphine while the remaining four received the placebo and the morphine.
Both objective and subjective signs of withdrawal were assessed and compared to the baseline survey [ 7 ].
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