Sixteen trials compared the potential benefits of chondroitin with that of a placebo. The data from the other three came from conference abstracts, meaning only a summary of results is available or they had poorly defined comparison groups. In this trial, participants received either three mg chondroitin sulphate capsules or one mg avocado soybean unsaponifiable capsule a day for six months. A second RCT randomly assigned participants to receive either one mg sachet of chondroitin sulphate or a sachet of placebo once a day for two years.
The participants of this study received one of the following doses three times a day for 24 months:. Osteoarthritis OA is the most common form of arthritis. It can cause joint pain and stiffness. Learn about the causes, symptoms and treatments. The information presented by TraceGains is for informational purposes only.
It is based on scientific studies human, animal, or in vitro , clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals.
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Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Chondroitin Sulfate. Uses Chondroitin sulfate consists of repeating chains of molecules called glycosaminoglycans GAGs.
What Are Star Ratings? This supplement has been used in connection with the following health conditions: Used for Why 3 Stars. Many trials have shown that supplementing with chondroitin sulfate reduces pain, increases joint mobility, and promotes healing within the joints. Applying an ointment containing chondroitin sulfate may speed healing of skin wounds. Preliminary research shows that chondroitin sulfate may prevent atherosclerosis and may also prevent heart attacks in people who already have atherosclerosis.
Taking chondroitin sulfate may reduce the risk of heart attack in people with a history of heart disease or who are at risk for heart attack. Years ago, researchers reported that taking for six years substantially reduced the risk of fatal and nonfatal heart attacks in people with. Chondroitin may work by inhibiting and by acting as an anticoagulant. The few doctors aware of these older studies sometimes recommend that people with a history of heart disease or who are at risk for heart attack take approximately mg of chondroitin sulfate three times per day.
Chondroitin sulfate has lowered serum cholesterol levels in preliminary trials. Years ago, this supplement dramatically reduced the risk of heart attacks in a controlled, six-year follow-up of people with heart disease. The few doctors aware of these older clinical trials sometimes tell people with a history of heart disease or elevated cholesterol levels, to take approximately mg of chondroitin sulfate three times per day.
Chondroitin sulfate may help reduce the risk of kidney stone formation. Chondroitin could also enhance the blood-thinning effects of vitamins and supplements such as fish oil and vitamin E. Talk to your doctor, however, before taking chondroitin, since it can take several months before you feel any improvements. Osteoarthritis Cartilage. Arthritis and Rheum. Busci L, Poor G.
Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis SYSADOA in the treatment of knee osteoarthritis.
Chavez ML. Glucosamine sulfate and chondroitin sulfates. Hosp Pharm. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. Das A, Hammond TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis.
Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am.
Firestein: Kelley's Textbook of Rheumatology. Philadelphia, PA: Elsevier Saunders; Clucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis Rheum. Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.
Potential effects of chondroitin sulfate on joint swelling: a GAIT report. Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth.
Exp Cell Res. Use of glucosamine and chondroitin supplements and risk of colorectal cancer. Cancer Causes Control. Kelly GS. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alt Med Rev. Chondroitin sulfate for the treatment of hip and knee osteoarthritis: current status and future trends.
Life Sci. Lamari FN. The potential of chondroitin sulfate as a therapeutic agent. Proponents say that when taken as a supplement, it increases the synthesis of various cartilage components while also preventing cartilage breakdown 4. A review of 26 studies showed that taking chondroitin supplements may improve pain symptoms and joint function compared with taking a placebo 5. A review suggests that it may slow the progression of OA, while also decreasing the need for nonsteroidal anti-inflammatory drugs, such as ibuprofen, which come with their own side effects 6.
On the other hand, several studies did not find enough evidence to suggest that chondroitin can help relieve OA symptoms, including joint stiffness or pain 7 , 8 , 9.
Several professional agencies, such as the Osteoarthritis Research Society International and the American College of Rheumatology, discourage people from using chondroitin due to the mixed evidence on its effectiveness 10 , While chondroitin supplements may address the symptoms of OA, they do not provide a permanent cure. This may include the following:. Healthcare professionals also often use chondroitin sulfate in a solution form during cataract surgery and other eye surgeries.
When combined with other compounds in a solution, chondroitin can help protect parts of the eye during surgery and help prevent complications Chondroitin is also an ingredient in several types of prescription eye drops that eye doctors often use for relieving dry, irritated eyes People most commonly use chondroitin sulfate supplements to help relieve symptoms of osteoarthritis, though data on its effectiveness is mixed.
Scientists need to do more research in this area. While taking chondroitin sulfate may help you control OA symptoms, it comes with a few potential downsides that you should be aware of. Taking chondroitin has been found to be safe.
However, one of the main potential side effects users may experience is stomach discomfort. More specifically, some people experience 17 :. You may be able to avoid an upset stomach by splitting your daily chondroitin dose into two different doses you take at different times of the day.
Some data suggest that chondroitin sulfate may interact with warfarin Coumadin , a common blood thinning medication 18 , As with most dietary supplements, people who are pregnant or breastfeeding should avoid taking chondroitin. While chondroitin sulfate may provide several joint health benefits, there are some downsides to be aware of.
As with many supplements, people who are pregnant or breastfeeding should not take chondroitin.
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