What happens if I have too much oestrone? What happens if I have too little oestrone? Last reviewed: Mar Prev. Related Topical issues. What is HRT? View all Topical issues. Related Endocrine Conditions. Related Hormones. Related Glands. Adrenal glands Ovaries Adipose tissue View all Glands. Related Glossary Supplements. The importance of this unique aspect of the tissue-specific regulation of aromatase expression lies in the fact that the low circulating levels of estrogens which are observed in postmenopausal women have little bearing on the concentrations of estrogen in, for example, a breast tumor, which can reach levels at least one order of magnitude greater than those present in the circulation, due to local synthesis within the breast.
Thus, the estrogen which is responsible for breast cancer development, for the maintenance of bone mineralization and for the maintenance of cognitive function is not circulating estrogen but rather that which is produced locally at these specific sites within the breast, bone and brain.
In breast adipose of breast cancer patients, aromatase activity and CYP19 expression are elevated. This occurs in response to tumor-derived factors such as prostaglandin E2 produced by breast tumor fibroblasts and epithelium as well as infiltrating macrophages. This increased CYP19 expression is associated with a switch in promoter usage from the normal adipose-specific promoter I. Since these two promoters are regulated by different cohorts of transcription factors and coactivators, it follows that the differential regulation of CYP19 expression via alternative promoters in disease-free and cancerous breast adipose tissue may permit the development of selective aromatase modulators SAMs that target the aberrant overexpression of aromatase in cancerous breast, whilst sparing estrogen synthesis in other sites such as normal adipose tissue, bone and brain.
Read more on Healthy Bones Australia website. The vaginal ring is a soft plastic ring which contains two types of hormones - an oestrogen and a progestogen. These hormones are similar to the ones made in your ovaries and are like the hormones that are in the contraceptive pill. Fibroids are benign non-cancerous growths of the uterus womb. The most common symptoms associated with fibroids are heavy or irregular periods, but often there are no symptoms.
Read more on myDr website. Read more on Better Health Channel website. What is osteoporosis? Find out what you need to know about osteoporosis and bone strength. Learn the difference between osteoporosis and osteopenia.
Osteoporosis is a condition characterised by weakened bones that fracture easily. After menopause many women are at risk of developing osteoporosis.
The female sex hormone oestrogen plays an important role in maintaining bone strength. After menopause oestrogen levels drop and this may result in increased bone loss.
The average woman loses up to 10 per cent of. Read more on Australasian Menopause Society website. The combined oral contraceptive pill is an effective contraceptive method which can also offer other benefits Read more on Australian Prescriber website.
Falling oestrogen, and not falling progesterone, levels are the trigger for the migraine in menstrual migraine. Calcium Supplements — a patient guide The use of calcium supplements has long been considered an integral part of managing osteoporosis, with detailed reviews of medical research indicating a reduction in fracture risk when calcium and vitamin D are prescribed.
In addition to the bone health benefits, there is also evidence that calcium supplements may improve cholesterol levels, blood pressure, c.
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